Abstract

ATTENUATION OF HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACEAL INTUBATION-‘A COMPARATIVE STUDY OF FENTANYL AND ESMOLOL.’

Dr. Amarjeet D. Patil, Dr. Baliram V. Ghodke, Dr. Sunita A. Patil

ABSTRACT

Background: Laryngoscopy and endotracheal intubation are integral part of induction of general anesthesia which cause to presser response leading to hemodynamic responses. Several techniques have been studied to attenuate this stress response but none of them are completely satisfactory hence there is a constant search for an ideal drug to attenuate hemodynamic response. Here we studied the hemodynamic response to laryngoscopy and endotracheal intubation and compare the relative efficacy of Esmolol and Fentanyl for attenuation of hemodynamic response during laryngoscopy and endotracheal intubation. Methods: After obtaining approval from the Institutional Ethics Committee and written informed consent form patients, 60 patients were randomly selected & allocated into two groups,Group I:Esmolol group &Group II: Fentanyl group of 30 each.Vital parameters (pulse rate and blood pressure) were measured at various intervals and compared. Multiple pair wise comparisons with Bonferroni’s adjustment done and ANOVA (analysis of variable) test was applied. Results: Significant difference was noted in hemodynamic parameters in both the groups. Conclusion: Intravenous Esmolol was found to be more effective than intravenous Fentanyl in attenuating presser response to laryngoscopy and intubation.

Keywords: Haemodynamic response, laryngoscopy, endotracheal intubation, fentanyl and esmolol.