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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

ANALYTICAL APPROACHES FOR KETOROLAC TROMETHAMIN: REVERSE PHASE HPLC AND UV SPECTROSCOPY METHODOLOGY

*Adhiraj Chauhan, Dr. Mukesh Bansal and Dr. Dilip Agrawal

ABSTRACT

This study presents analytical methodologies for the determination of ketorolac tromethamine, a nonsteroidal anti-inflammatory drug, employing reverse-phase high-performance liquid chromatography (RP-HPLC) and UV spectroscopy. The RP-HPLC method utilizes a C18 column and a mobile phase comprising acetonitrile and phosphate buffer, demonstrating high specificity and precision. UV spectroscopy involves the measurement of absorbance at a wavelength of maximum absorption. Both methods exhibit excellent linearity, accuracy, and sensitivity for ketorolac tromethamine quantification. These validated techniques offer reliable tools for pharmaceutical quality control, ensuring accurate dosage assessment and potency evaluation in formulations containing ketorolac tromethamine.

Keywords: Chromatography, HPLC and UV spectroscopy, Instrumentation, Applications, Methodology.

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