Abstract

REVIEW ON SYNTHESIS THIOPHENE DERIVETIVES AND THEIR PHARMACOLOGICAL ACTIVITY

*Sushama H. Bhasmare, Ass. P. Mary D. Magar

ABSTRACT

Thiophene derivatives have gained considerable attention in the field of medicinal chemistry due to their diverse pharmacological activities. This research focuses on the synthesis of novel thiophene derivatives and the evaluation of their potential pharmacological effects.[1] A series of thiophene-based compounds were synthesized using efficient and environmentally friendly synthetic methodologies. The chemical structures of the synthesized compounds were characterized using various spectroscopic techniques, including NMR, IR, and mass spectrometry.[2] Furthermore, structure-activity relationship (SAR) studies were conducted to elucidate the key structural features responsible for the observed biological activities. The SAR analysis provides valuable insights into the design and optimization of thiophene derivatives with enhanced pharmacological properties.[3] In conclusion, the synthesis of thiophene derivatives presented in this study demonstrates a successful strategy for the development of bioactive compounds with potential therapeutic applications.[4] The pharmacological evaluation highlights the versatility of thiophene derivatives as valuable candidates for further optimization and development as drug candidates. This research contributes to the growing body of knowledge in the design and synthesis of heterocyclic compounds with diverse pharmacological activities.[5]

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