Abstract

EFFECT OF HYDROPHILIC SWELLABLE POLYMER ON DISSOLUTION RATE OF PARACETAMOL USING SIMPLE PHYSICAL MIXING TECHNIQUE

Kamalesh Upreti, Lalit Kumar, Akash Kirsali, Stutie Pathak Anand, Viney Chawla*

ABSTRACT

In case of poorly aqueous soluble drugs, solubility plays a major role in drug dissolution. The rate of oral absorption of these drugs is controlled by their dissolution in the gastrointestinal tract. Thus, solubility and dissolution rate are the key determinants of oral bioavailability. Poorly soluble drugs are dispersed in an inert hydrophilic polymer or matrix by physical mixing, melting, solution formation, or solvent melting to yield solid dispersion in order to enhance drug dissolution and bioavailability. The present study explores the potential of hydrophilic swellable polymers such as sodium carboxymethyl cellulose (NaCMC) and hydroxypropyl methyl cellulose (HPMC) which have still been unexplored for their potential to form solid dispersion. For this reason, in the present work, water-swellable polymers were used along with other excipients of solid dosage forms. These polymers are expected to hold the drug in intimate contact with water owing to their water retention potential and increase its wettability. The present study recorded the effect of hydrophilic swellable polymers on dissolution rate of Paracetamol (PCM). The percent drug release of HPMC+PCM in one hour was greater than CMC+PCM i.e. 58.76% and 43.08%.

Keywords: Paracetamol, Hydroxy propylmethyl cellulose, sodium carboxy methyl cellulose, water swellable polymer.