Abstract

FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLET OF DROTAVARINE HCl

Priyanka Kale*, Sadhana R. Shahi, Anil Battase and Manjari N. Bobde

ABSTRACT

Antispasmodic medication Drotaverine hydrochloride (DRH) has a short half-life in the colon during diarrhoea, resulting in low bioavailability and frequent doses. The current study's objective was to prolong the stomach residence duration and maintain the release of DRH, hence improving patient compliance. Floating tablets of DRH were formulated using various polymer dosages and a 32- design. The produced formulas were examined for a number of physical characteristics, floating behaviour, and in vitro release tests. Formula F2 (HPMC K4M 60mg and Carbopol 10mg) showed optimum floating behaviour (floating lag time 30±5.3s 19 and total floating time ˃12h) and optimum sustained release for DRH (64.75±0.76% after 8 hr 20 and 78.14±3.10% after 12h). The results revealed that F2 could be a promising candidate for gastro retentive drug delivery systems for DRH.

Keywords: Drotavarine hydrochloride, Carbopol-934, floating matrix tablet.