Abstract

PREPARATION, EVALUATION AND COMPARATIVE STUDY OF FLOATING DRUG DELIVERY SYSTEM OF BROAD SPECTRUM ANTIBACTERIAL DRUG

Poonam Abhimanyu Salunke*, Rupali Suresh Wagh, Shital Vikas Patil, Shital Shantaram Patil, Dr. S.D.Barhate

ABSTRACT

The present study was an attempt to develop floating tablets of Ciprofloxacin Hcl which on oral administration prolongs its gastric residence time thereby increasing bioavailability, diminishing side effects and enhanced patient compliance. Ciprofloxacin an antibacterial having narrow absorption window in the upper part of gastrointestinal tract, Thus, Floating tablets were prepared using directly compression technique using polymers like Tamarind cmc, HPMC K4M, Ethyl Cellulose for their gel-forming properties. The HPMC alone polymer unable to controlled on release rate it release drug >90% in 12 hrs while in combination with Tamarind cmc it release >90% in 12 hrs. The results indicate that gas generated gastro retentive floating Tablets of Ciprofloxacin HCL containing Tamarind cmc and HPMCK4 provides a better option for controlled release action and improved bioavailability.

Keywords: Ciprofloxacin HCL, floating drug delivery system, Tamarind cmc, gastrointestinal tract, Swelling study, floating study.