Abstract

SYNERGISTIC PROTECTIVE EFFECTS OF N-ACETYLCYSTEINE AND BETAINE AGAINST FLORFENICOL-INDUCED HEPATORENAL TOXICITY AND AFFECTS INTESTINAL INTEGRITY IN BROILER CHICKENS

Elrefaey Aboelftouh*, Ashraf Elkomy, Soad Saad Belih and Faten Elsayed

ABSTRACT

This study was aimed to evaluate the ameliorative role of N-acetylcysteine (NAC) and Betaine on florfenicol induced hepatorenal toxicity in broilers. A total of 150 broiler chicks were grouped into 5 groups each of 30 chicks. Group one was kept as a control group, while group 2 was treated with florfenicol by toxic dose (60 mg ̸kg body weigh) once daily orally for 5 days. Group 3 treated with betaine 1ml (40%) ̸ L of water for 5 days days of age. while group 4 treated with N-acetylcysteine (NAC) 100mg ̸ L of water for 5 days days of age. Group 5 treated with N-acetylcysteine (NAC) 100 mg ̸ L + Betaine1ml (40%) ̸ L of water for 5 days and florfenicol by toxic dose (60 mg ̸ kg body weigh) once daily orally for 5 days. All treatments were from 18 to 22 days of age. The biochemical analysis of liver, kidney indices, and histopathological examination were performed to evaluate their effects. Results showed that florfenicol induced hepatorenal toxicity in broilers and N-acetylcysteine (NAC) + Betainecan ameliorate its action which reflected by an enhancement in liver indices, antioxidant profile, and histopathological findings.

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