Abstract

MECHANISTIC STUDY OF PALLADIUM (II) CATALYZED OXIDATION OF ASPIRIN BY SODIUM PER IODATE(NAIO4): IN PERCHLORIC ACID MEDIUM

Sheila Srivastava and *Reena patel

ABSTRACT

Kinetic investigation of Pd (II) catalyzed oxidation of Aspirin by sodium per iodate (NaIO4) in acidic medium has been studied in the temperature range 30-450C. The reaction is carried out in the presence of mercuric acetate as a scavenger for iodide ion. The rate shows first order kinetics with respect to the catalyst i.e. Pd(II) while less than unit order with respect to substrate i.e. Aspirin is observed. Experimental result shows zero order kinetics with respect to oxidant i.e. [NaIO4] and [H+]. Negligible effect of mercuric acetate and ionic strength of the medium was observed and the reaction showed negative effect with respect to [Cl-]. A suitable mechanism in conformity with the kinetic observations has been proposed and the thermodynamic parameters computed.

Keywords: Kinetics, Oxidation, Pd (II), Periodate, Aspirin