Abstract

DEVELOPMENT AND EVALUATION OF FLOATING SUSTAINED RELEASE BILAYER TABLETS CONTAINING CYPROHEPTADINE HYDROCHLORIDE

Manoj Yr* and Dr. K. Manjunath

ABSTRACT

To increase the retention of the dosage form in the stomach, gastro retentive drug delivery systems are frequently used. Bilayer floating tablets formulation, out of all methods, offers sustained drug release, prolonged stomach retention, and the benefit of liquid oral dose form. Using the direct compression method, the current effort aims to create bilayered floating tablets of cyproheptadine HCl. Bilayer tablet of Cyproheptadine HCl contained sodium starch glycolate as a super disintegrant and sustained release layer contained HPMC K4M, HPMC K100, xanthan gum, guar gum, karaya gum and locust bean gum to release the drug for 12 hrs time. Sodium bicarbonate and citric acid as effervescent agent. There was no interaction between the drug and excipients in FTIR studies conducted for the development of bilayer tablets. The manufactured floating bilayered tablets underwent in vitro dissolution tests as well as weight variation, thickness, friability,hardness, and drug content uniformity evaluations. The formulation F6 with HPMC K4M, Xanthan gum, and guar gum showed the maximum amount of drug release of 96.83% up to 12 hours, following zero order kinetics, out of all formulations F1 to F10.

Keywords: Gastro retentive drug delivery system, Floating bilayer tablet, Cyproheptadine HCl, HPMC K4M, Xanthan gum, Guar gum, FTIR.