Abstract

PHARMACOGNOSTICAL AND PHARMACEUTICAL ANALYSIS OF DASHAMOOLA YAVAKOOTA & DASHAMOOLA KSHEERA KASHAYA- AN EXTERNAL APPLICATION

Hiral Patel*, Rahul S. Gandhi and Harisha C. R.

ABSTRACT

Introduction: Diabetic neuropathy is a type of nerve damage that can occur with uncontrolled diabetes. High blood sugar can injure nerves throughout the body. Diabetic neuropathy most often damages nerves in the legs and feet. It is a serious diabetes complication that may affect as many as 50% of people with diabetes.[1] Symptoms include: numbness or reduced ability to feel pain or temperature changes, tingling or burning feeling, sharp pains, muscle weakness, extreme sensitivity to touch.[2] In Ayurveda can’t be straightforwardly corelated with any disease, but can be Analogue with the symptoms of Prameha upadrava or Madhumeha or Prameha Poorvarupa other scattered references are available in text, which are mainly Vata-Pitta dominant. so, treatment which is Vata-Pitta shamaka should be initiated. And effort by this paper that Dashamoola ksheera Kashaya Parisheka is useful. Aim: to standardize Dashamoola yavakoota Pharmacognostically, physiochemically and phytochemically. Materials and methods: Dashamoola yavakoota were collected from local market of Jamnagar, were identified and authenticated Pharmacognostical and Pharmaceutical parameters, high performance thin layer chromatography has been performed as per standard method. Results: The pharmacognostical study reveals the presence of Annular vessels of Kantakari, cork surface view of Shyonaka, crystal of Gambhari, fibres along with brown cantante of Bilwa, fibres of Bilwa, fibres of Gambhari, lignified stone cells of Shyonaka, cork cells of Agnimantha, crystal fibres of Bilwa, epicarp cells of Kantakari, fibres of Agnimantha, fibres of Brihati, etc. many more. Pharmaceutical analysis showed that loss on drying was 7.77% W/W, Ash value was 5.63% W/W, water soluble extractive was 0.9% W/W, methanol soluble extractive was 21.24% W/W, pH value of Dashamoola yavakoota was 6 and pH value of Dashamoola ksheera was 7 (by pH meter), specific gravity of Dashmoola ksheera was 0.94. HPTLC profile of Dashamoola Kashaya revealed 4 spots at 254nm and 22 spots at 366nm. Conclusion: The present investigation will be helpful in assessing the Pharmacognostical, phytochemical analysis and laying down pharmacopeial standards for Dashamoola Kashaya.

Keywords: Dashmoola yavakoota, Dashmoola ksheera Kashaya, Dashamoola Kashaya, HPTLC, Pharmacognosy, Pharmaceutics.