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FORMULATION AND EVALUATION OF METHYL PREDNISOLONE LOADED MICROSPONGES FOR COLON DRUG DELIVERY: PHARMACOKINETIC AND IN-VITRO STUDY
Ravi Dnyandeo Hole* and Vishal Bharat Babar
ABSTRACT
The aim of this study was to develop Methyl prednisolone Loaded micro sponges for colon specific drug delivery. The micro sponges formulations were prepared by QESD technique (solvent diffusion method) employing eudragit RS 100 as a polymer. The compatibility of the drug with formulation components was established by Fourier Transform Infra-Red (FTIR) spectroscopy. Afterwards, micro sponge formulations were prepared by gradually increasing the drug: polymer ratio. The surface morphology, particle size, production yield, and drug entrapment efficiency of micro sponges were examined. Shape and surface morphology of the micro sponges were examined using scanning electron microscopy. Particle size of prepared micro sponges was observed in the range of 465 ± 10.5 to 80.2 ± 15 μm. The drug Keywords: Micro sponges, QESD technique Eudragit Rs 100, Methyl prednisolone, Polyvinyl Alcohol. [Download Article] [Download Certifiate] |