Abstract

A REVIEW ON HUNTINGTON’S DISEASE

Srikrishna T., Y. Prapurnachandra, P. Venugopalaih, K. Harika*, L. Nichitha, O. Nikhil, J. Chandrika and T. Thulasi

ABSTRACT

Huntington's disease (HD) is a neurodegenerative disorder characterized by severe motor, cognitive and psychiatric symptoms. Patients of all ages can present with a dysfunction of the nervous system, which leads to the progressive loss of movement control and disabilities in speech, swallowing, communications, etc. Given that Huntington's disease (HD) is caused by a defective gene that encodes the trinucleotide expansion, the disease's molecular cause is well understood. Neurodegenerative diseases result from the loss of this protein's function, which is connected to neurogenesis. Despite the fact that the disorder's hereditary basis has been known for many years, there is currently no proven way to stop the disorder's symptoms from starting or from progressing. In order to support the development of treatments that may lessen the severity of the symptoms and manage their course, the current evaluation thus concentrated on the creation of innovative techniques for the prompt and accurate diagnosis of HD. The majority of treatments involve the use of different chemicals as medications with extremely encouraging outcomes, as well as gene-silencing techniques of the mutant Huntington gene intended to suppress its production. The most recent methods for diagnosing HD are included in this study, along with the necessity of genetic counselling and a current overview of the available treatments.

Keywords: Huntington's disease, defective gene, preclinical and neurodegenerative disorder.