Abstract

FORMULATION STRATEGY FOR DISSOLUTION ENHANCEMENT OF ATOVAQUNE

*Savita Shimple

ABSTRACT

The aim of present work was “Formulation strategy for Dissolution Enhancement of Atovaquone”. Atovaquone is a hydroxy-1,4-naphthoquinone, used for the prevention and treatment of Pneumocystis jevorici (formerly carinii) pneumonia and prevention and treatment of P. falciparum malaria. The main aim of this study was to enhance the dissolution rate of a poorly water-soluble antimalarial drug, Atovaquone , by „” Formulation Development and Evaluation of Immediate Release Tablet”. Methods: Immediate release tablet was prepared by Direct Compression method. Weight accurately all ingredient like drug and excipient (e.g. Microcrystalline Cellulose, Starch, SLS, talk, Magnesium stearate ). Pass all ingredient in sieve no. 18 individually . Then mix all ingredient properly in mortar and pestle and pass through sieve no. 60. Tablets was prepared by direct compression method. Author:- Savita Shimple, Nitin Tribhuvan, Aniket Deshmukh. Shri. Bhagawan college of Pharmacy, Aurangabad, N-6 Cidco. 431003. Result: On the basis of in vitro dissolution, starch and ,Sodium Lauryl Sulphate was superior to improve dissolution rate of poorly water soluble drug. Conclusion: Immediate release tablet formulation use to improve dissolution rate of poorly water soluble antimalarial drug, Atovaquone .

Keywords: Atovaquone , Starch , SLS , MCC , Immediate release , dissolution rate , Solubility , in vitro dissolution