Abstract

POTENTIAL INTERACTIONS OF ANTIHYPERTENSIVE DRUGS IN HEMORRHAGIC STROKE PATIENTS AT THE NEUROLOGY WARD OF DR. M DJAMIL GENERAL HOSPITAL, PADANG

Meta Emilia Surya Dharma*, Suhatri and Vany Anggrainy

ABSTRACT

Hemorrhagic stroke is a cardiovascular disease that can cause death. In general, hemorrhagic strokes use more than one drug therapy, so that it has the potential to facilitate drug interactions. The purpose of this study was to determine the potential for antihypertensive drug interactions with other drugs in the treatment of hemorrhagic stroke patients at the neuro inpatient installation at M Djamil General Hospital, Padang. This research is a descriptive observational study with retrospective data collection using purposive sampling technique. The research instrument used was medical record data of hemorrhagic stroke patients. Data analysis was determined by looking at the potential for drug interactions using : Drugs.com and Medscape. From the results of the research that was conducted, it was found that 72 patients were included in the inclusion criteria. The results obtainedwere 65 drug interactions from 58 patients. There were 30 cases of potential pharmacokinetic interactions with a percentage of 43% and cases of potential pharmacodynamic drug interactions there were 35 cases with a percentage of 57%. As well as 2 cases with potential severity of major with a percentage of 4%, 57 cases with potential for moderate severity with a percentage of 88% and 5 cases with potential for minor severity with a percentage of 8%. It can be concluded that the drug interaction that often occurs in inpatients with hemorrhagic stroke patients at M Djamil General Hospital Padang is the combination of amlodipine with haloperidol and codeine.

Keywords: Hemorrhagic stroke, Drug interactions, Antihypertensives.