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A REVIEW OF ANALYTICAL METHOD DEVELOPED & VALIDATED FOR ESTIMATION OF SAXAGLIPTIN
Vaghela Kuldeepsinh*, Maheshwari Deep, Komal Rana, Kalesh Kapila and Bhagirath Patel
ABSTRACT
This review covers various analytical techniques such as chromatography (HPLC, LC - MS, HPTLC), (UV – Vis spectroscopy), methods. Furthermore, it discusses sample preparation, validation parameters, and recent advancements in saxagliptin analysis. This study presents a robust and validated analytical method for the quantitative determination of saxagliptin, a potent dipeptidyl peptidase-4 (DPP-4) inhibitor used in the management of type 2 diabetes, in tablet formulations. The method utilizes high-performance liquid chromatography (HPLC) coupled with a UV-visible detector, offering excellent sensitivity and specificity for saxagliptin analysis. Calibration standards covering a range of clinically relevant concentrations are prepared and analyzed to construct a linear calibration curve. The method exhibits excellent linearity (R² > 0.999) over the specified Keywords: Saxagliptin, Type 2 Diabetes, HPLC, HPTLC, LC-MS, UV Visible SPECTROSCOPY. [Download Article] [Download Certifiate] |