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ASSESSMENT OF CHRONIC ADMINISTRATION OF AMLODIPINE IN CEREBELLUM OF WISTAR RATS
Ponle Bamidele Fakunle*, Israel Oguns Ogunyemi and Samuel Ehireme
ABSTRACT
Hypertension, a prevalent cardiovascular condition, necessitates effective management through antihypertensive medications. Amlodipine, a widely prescribed calcium channel blocker, exhibits potent antihypertensive effects. However, its comprehensive impact on physiological parameters, especially the cerebellum, remains inadequately explored. We conducted an in-depth investigation into the impact of Amlodipine on various biological systems. Male Wistar rats were administered Amlodipine at three different doses (T1: 2.5mg/kg, T2: 5mg/kg, T3: 10mg/kg) for two weeks. Hematological indices, antioxidant defenses, and cerebellum morphology were meticulously examined. Our study revealed a significant increase in red blood cell (RBC) counts in the T2 and T3 groups, indicating a dose-dependent Keywords: Amlodipine, Hypertension, Hematological indices, Antioxidant enzymes, Cerebellum. [Download Article] [Download Certifiate] |