FORMULATION AND EVALUATION OF PHYSICO-CHEMICAL CHARACTERIZATION OF NANOEMULSION CONTAINING ANTI ALZHIEMERS DRUG (RIVASTIGMINE)
K. Thamizhvanan*, Mallikarjuna B. P., Shaik Mubeena, L. Kiran and R. Sudharshana Aditya
ABSTRACT
Solubility of Rivastigmine was determined in various oils, surfactants and co surfactants. Excipients with maximum solubility were further chosen for preparing the mixtures in different ratios (surfactant: co- surfactant and oil S mix) to determines suitable combination of oil, surfactant and co-surfactant. To the combinations that gave absolute transparency when mixed with Milli-Q water, drug was added till the concentration of 10mg/ml. The finalized samples were vortexed and kept overnight. The finalized combination was selected and further subjected to ultra sonication method.
Keywords: Rivastigmine, Surfactants, Excipients, Milli Q, Ultrasonication, SLS solution, UV Visible spectrophotometer.
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