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ADJUNCTIVE USE OF METFORMIN + ROSUVASTATIN IN SCHIZO-AFFECTIVE DISORDER: A CASE REPORT AND MINI-REVIEW OF RELATED MECHANISMS
*Dr. Stephen E. O. Oriaifo, Prof. B. Adegboro, Dr. Donald Odion Oriafo, Dr. Ronald Akhere Oriaifo and Dr. Stellamaris O. Obende
ABSTRACT
Extant hypotheses of bipolar disorder and stress-response associated pathways appear to converge on genetic and environmental effects on mitochondrial epigenome-nuclear genome –induced phenotypic changes in T lymphocytes. Immune homeostasis of T cells are now recognized as vital part of the body’s response to safely adjust to stress-induced excessive behaviours. Workers have also linked immune cytokines with modulators of psychological status, such as the oxytocin secreting system, in the general population. Diabetes, a risk-equivalent for coronary artery disease, and dyslipidemia are linked to bipolar disorder, a disease rooted in genetics and boosted/lifted by gene-environment interactions. Increasingly, the psychiatric potential of statins in severe mental illnesses and of also of metformin-mimetics Keywords: Schizo-affective disorder, Gene-Environment; CD 28null T cells, Metformin, Rosuvastatin, Prolactin; Depixol. [Download Article] [Download Certifiate] |