Abstract

THE PRONIOSOMES DEVELOPMENT AND OPTIMIZATION AS A SURROGATED DRUG CARRIER FOR ORAL DELIVERY OF GLICLAZIDE. AN-OVERVIEW

Rishikesh Gupta, Santosh Kumar *, Nikhil Gupta , Virendra Kumar, Dr. S K Prajapati and Anurag Kumar 

ABSTRACT

The novel drug delivery systems have various routes of administration to achieve controlled drug release and targeted drug delivery. Encapsulation of the drug in vesicular structures, which can be predicted to prolong the existence of the drug in systemic circulation and reduce the toxicity, if selective uptake can be achieved. Consequently, a number of vesicular drug delivery systems such as liposomes, niosomes, transferosomes, ethosomes and proniosomes were developed. Proniosomes are water soluble carrier particles that are coated with surfactants and can be hydrated to form a niosomal dispersion immediately before use on brief agitation in hot aqueous media. Proniosomes are very promising as drug carriers. The formulation study on Gliclazide is an attempt to prepare proniosome based niosomal drug delivery system using maltodextrin as carrier and to evaluate its performance. The proniosomes with various types and contents of nonionic surfactant and cholesterol is evaluated in this study. An ideal or best formulation of proniosomes based niosome is said to be one which gives high entrapment drug efficiency with desirable sustained release. In this study entrapment efficiency is found to be cholesterol: surfactant ratio dependent. The release rate also found to be dependent of cholesterol: surfactant ratio. For effective proniosomes, it is essential that the surfactant coating be smooth and uniform to allow for rapid and consistent hydration. SEM study reveals that the coating of the surfactant on the maltodextrin powder is uniform. Angle of repose measurements indicated that the fluidity of proniosomes dry powder is equal to or better than that of maltodextrin powder, so further processing of proniosomes powder should be straightforward.

Keywords: Proniosomes, span 60, cholesterol, maltodextrine and gliclazide.