Abstract

SYNTHESIS, CHARACTERZATION AND BIOLOGICAL EVALUAVTION OF 2-(SUBSTITUTED THIAZOLIDINE -4-ONE)-1H -PHENYL BENZIMIDAZOLE

Kadapal Gopal*, D. Radha, Sidde Lahari, A. Ishwarya, E. Kavitha, K. Suchitra, K. Pavan Kumar and G. Maruthi Prasad

ABSTRACT

Benimidazole and its derivatives belong to a class of benzo-fused heterocyclic compounds. The presence of the thiazolidinone ring in a benzimidazole derivative enhances its pharmacological activity. Benimidazole derivatives have wide spectrum of biological activities like anti-hypertensive, anti-viral, anti-fungal, anti-tumor, analgesic and anthelmintic activity. A new series of 2-(substituted thiazolidine -4-one-1H-phenyl benzimidazole) were synthesized by three steps. By reacting ortho phenylene diamine with Para amino benzoic acid in acidic medium which leads to formation of 2-(4-amino phenyl) benzimidazole. 2-(4-amino phenyl) benzimidazole is treated with substituted aromatic aldehyde by using ethanol as a solvent and glacial acetic acid as catalyst gives Schiff‘s base. The obtained Schiff base was treated thioglycolic acid using DMF as solvent and zinc chloride as catalyst.The chemical structure of synthesized compound was confirmed by physical, IR spectral and elemental analysis data. The synthesized compounds were screened for analgesic activity by using tail flick method and anthelmintic activity by earth worms. The synthesized compound showed significant activity comparable to that of standard.

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