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FORMULATION AND EVALUATION OF MATRIX TABLETS FOR DELIVERY OF METHYL PREDNISOLONE SPECIFICALLY TO THE COLON
Ravi Dnyandeo Hole* and Vishal Bharat Babar
ABSTRACT
The current study produced and assessed tamarind seed polyose and guar gum-based matrix tablets for the colon-targeted administration of methyl prednisolone acetate. The matrix tablets were made using the wet granulation procedure. The weight and medicine content of each pill were both consistent, with low SD values. Both the hardness and brittleness were within acceptable limits. According to the DSC & FTIR analyses, the drug is stable in the formulations. The uncoated tablets had a slightly rough surface compared to the smooth surfaces of the tablets coated with rosin and ERS, and the porous film that covered the surfaces of the PMMA-coated tablets. Utilising a dissolving rate test device in gastric and intestinal fluids, an in-vitro drug release investigation was carried out. Since the uncoated tablets did not Keywords: Colon targeting, Methyl Prednisolone Acetate, X - Ray study. [Download Article] [Download Certifiate] |