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A REVIEW ON SOLID DISPERSION
Kritika Thakur*, Meenu Nagpal, Geeta Aggarwal, Rupinder Kaur, Sukhdev Singh, Tapan Behl, Upendra Kumar Jain
ABSTRACT
Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. The dissolution rate could be the rate-limiting process in the absorption of a drug from a solid dosage form of relatively insoluble drugs. Therefore increase in dissolution of poorly soluble drugs by solid dispersion technique represents a challenge to the formulation scientists. Solid dispersion techniques have attracted considerable interest of improving the dissolution rate of highly lipophilic drugs thereby improving their bioavailability by reducing drug particle size, improving wettability and forming amorphous Keywords: Poorly soluble drug; solid dispersion; solubility enhancement. [Download Article] [Download Certifiate] |