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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF VALACYCLOVIR HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM BY UV-SPECTROPHOTOMETRIC METHOD”
Bhavya K. B.*, Chandu M., Darshan Gowda L. M., Hithesh P.,
ABSTRACT A New, simple, accurate and precise Zero order derivative spectroscopic method was developed and validated for the estimation of Valacyclovir Hydrochloride in bulk and Tablet dosage form. The stock solution was prepared by weighing 100 mg of standard Valacyclovir Hydrochloride in 100 ml volumetric flask with 0.1N NaOH. The stock solution was made to produce 1000 μg/ml with 0.1N NaOH. Further dilutions were prepared as per procedure. The drug solution showed the maximum absorbance at 257 nm. The linearity was found in the concentration range of 5-25 μg/ml. The correlation coefficient was found to be 0.999. The regression equation was found to be Y=0.0391x+0.0002. The method was validated for linearity, accuracy, precision, ruggedness, robustness, LOD and LOQ. The LOD and LOQ for estimation of Valacyclovir Hydrochloride were found to be 0.000176 μg/ml and 0.0 μg/ml respectively. Recovery of Amlodipine was found to be in the range of 99.58-101.63 %. Proposed method was successfully applied for the quantitative determination of Valacyclovir Hydrochloride in bulk and Tablet dosage form. Keywords: Valacyclovir Hydrochloride Zero order UV- Spectroscopy, 0.1N NaoH, Accuracy. [Download Article] [Download Certifiate] |