Abstract

IN-VITRO EVALUATION OF ACECLOFENAC SUSTAINED RELEASE LIPOSPHERES FORMULATED FROM SUS SCROFA DOMESTICUS FAT EMULSIFIED BASE

Osita C. Uzochukwu* and Florence E. Eichie

ABSTRACT

An emulsion is a disperse system made up of two immiscible phases (oil and aqueous phases) in which one of the phases is subdivided into minute globules/droplets and distributed uniformly in the other and stabilized by an emulsifying agent. Though thermodynamically unstable emulsified systems have found a wide application as a dosage form in drug delivery system in oral, topical and parenteral formulations and nutrition (Jadhav et al; 2006, Tenjala 1999; Nasr et al; 2008 and Rai et al; 2016). Emulsion as a dosage form has also enabled the formulation of immiscible phases together in the same formulation such as oil soluble and water-soluble ingredients in the same dosage forms, it helps in improvement of the consistency of certain oily drugs commonly used as laxatives and nutrients used in the feeding of dilapidated patients and in the retention of volatile oily components in certain formulations and emulsion can be used to prolong the release of drug thereby providing sustained release action. (Nandy and Mazumder 2014, Maheen and Rsul 2020, Siepman and Peppas 2001).

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