Abstract

REVIEW ON RHEUMATOID ARTHRITIS ITS MANAGEMENT AND TREATMENT

Vishwakarma Shivani*, Shrivastava Khare Ruchi and Pathak Vishwas

ABSTRACT

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that predominantly affects the lining of the synovial joints and is associated with progressive disability, early death, and socioeconomic burdens. A better understanding of how the pathological mechanisms drive the deterioration of RA progress in individuals is urgently required in order to develop therapies that will effectively treat patients at each stage of the disease progress. Here we dissect the etiology and pathology at specific phases: (i) triggering, (ii) maturation, (iii) targeting, and (iv) fulminant stage, concomitant with hyperplastic synovium, cartilage damage, bone erosion, and systemic consequences. Modern therapies remain the mainstay of RA treatment and there has been significant progress toward achieving disease remission without joint deformity. Despite this, a significant proportion of RA patients do not effectively respond to the current therapies and thus new drug therapy. This review discusses understanding of RA pathophysiology, available drugs, and provides perspectives on next generation therapeutics for RA.

Keywords: Rheumatoid Arthritis, Osteoarthritis.