Abstract

AN EFFICIENT SYNTHESIS AND POTENTIAL ANTIMICROBIAL EVALUATION OF NOVEL 1,2,3-TRIAZOLE-PYRAZOLE HYBRIDS

Meet J. Sherashiya*, Dilip C. Kanjariya, Vipul B. Audichya, Nilesh R. Kanzariya, Parth R. Barbhaya, Yogesh T. Naliapara and Smita Jauhari

ABSTRACT

The design and synthesis of a series of novel 1,2,3-triazole-pyrazole derivatives 6(a-j) target molecules have been synthesized by formyl pyrazole derivatives 5(a-j) and 5-methyl-1-(4-nitrophenyl)-1H-1,2,3- triazole-4-carbohydrazide 3 in the presence of an acidic medium. The corresponding formyl pyrazole derivatives were synthesized from the schiff bases of phenyl hydrazine or 4-nitrophenyl hydrazine and substituted acetophenones. 5-methyl-1-(4-nitro phenyl)-1H-1,2,3- triazole-4-carbohydrazide was produced from 4-nitroaniline. A straightforward and efficient synthesis of novel 1,2,3-triazole-pyrazole hybrids bearing a pyrazole ring has been demonstrated with excellent yields. Structures of novel 1,2,3-triazole-pyrazole hybrids 6(a-j) were confirmed by elemental analysis and 1H NMR, 13C NMR, Mass, IR spectral studies. The novel synthesized chemical entities were examined for their potential in vitro antimicrobial activity using Chloramphenicol, Ciprofloxacin, Nystatin, and Griseofulvin as standard drugs. In particular, compounds 6c, 6e, and 6g exhibited excellent anti-microbial activity against standard drugs.

Keywords: 1,2,3-Triazole, Pyrazole, Hydrazones, Schiff bases, Antimicrobial activity.