![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
SYNTHESIS AND EVALUATION OF NOVEL BENZOTHIAZOLE DERIVATIVES FOR ITS ANTI-ARTHRITIS ACTIVITY
*Vandana Pandey and Abhinav Prasoon Mishra
ABSTRACT It is an inflammatory form of arthritis that can affect areas outside the joints.[1] It is chronic inflammatory illness most commonly caused by genetic predisposition and environmental factors, especially cigarette smoking. Benzothiazoles are heterocyclic dicyclic molecules with a benzene atom connected to a ring with nitrogen and sulfur atoms. The melting point of benzothiazole is 2ºC, and the boiling point is 227- 228ºC. Benzothiazole has a molecular mass of 135.19 g/mol and a density of 1.24g/ml. In the home, benzothiazole serves no purpose. It has practical and academic applications. This research was based on the synthesis and evaluation of novel benzothiazole derivatives for its anti-arthritis activity. Novel derivatives of benzothiazoles were synthesized using substituted aniline. They were determined for physical properties, i.e., melting point was determined as 3ºC, 4ºC, 3ºC, 2ºC, 3ºC and 2ºC for the benzothiazole derivatives C1, C2, C3, C4, C5 and C6, respectively. TLC stands for thin layer chromatography and is used in synthetic chemistry to infer the production of a molecule based on its Rf value, which varies depending on the compound. Rf value was obtained as 0.67, 0.72, 0.79, 0.68, 0.73 and 0.79 of C1, C2, C3, C4, C5 and C6, respectively. While determining antirheumatic arthritis effect, different derivatives of benzothiazole were evaluated for rheumatoid factor. In conclusion, C1 demonstrated rheumatoid factor as 4.68±0.12, 8.83±0.19, and 6.17±0.16 in group 1, 2, and 3, respectively. Fellow researchers will evaluate the mode of action that how benzothiazole derivatives treat and prevent the progression of rheumatoid arthritis. Keywords: Benzothiazole, anti-arthritis, RA, TLC and FTIR. [Download Article] [Download Certifiate] |