Abstract

A REVIEW ON ORAL IN SITU GEL FOR PERIODONTITIS

Dr. K.M Manjanna*, Divya G.N, Geetha A, Dharmendra Singh, S. Venkata Lokesh, Arvind C

ABSTRACT

Periodontitis is a microbial disease that leads to inflammation in the tooth-supporting tissues of the oral cavity that is common among the elderly. It is induced by oral inflammation induced by bacterial dysbiosis. Several antimicrobial agents have been used effectively in the management of periodontal infection. In the past few years, an increasing number of in situ forming systems have been reported in the literature for various biomedical applications including the drug delivery systems. In this review, we have explained the methods of oral in situ gel for drug delivery and tissue repairing for Periodontitis. Oral in situ gel is the most suitable type of formulation for the treatment of Periodontitis, because it delivers the drug locally, since the disease is confined to the periodontal pocket, minimizes the toxicity with low dose of medicament. There are several mechanism which leads to the formation of in situ gel; effect of solvent exchange, UV-radiation, pH, ionic cross-linkage and temperature. This article provides the information on polymers used in formulation of in situ gel systems as well as formulation mechanisms based on temperature triggered system, ionic cross linking system, pH triggered system etc. Finally, this review summarize about the characterization of oral in situ gels including the different evaluation parameters such as visual appearance, surface pH, viscosity, Syringeability, gelation temperature, gelation time, in-vitro gelling capacity, drug content and drug release.

Keywords: Periodontitis, In situ gel, Mucoadhesive, Polymers.