Abstract

ANTI-MICROBIAL PROPERTIES OF COROSOLIC ACID FROM ACETONE LEAF EXTRACTS OF LAGERSTROEMIA SPECIOSA (L.) PERS (LYTHRACEAE) ON EXCISION WOUND MICROBES

Hari Kishan P. B., Pavithran S., Ganesan G., Karthik M., Maivizhi V. and Dr. P. S. Sujatha*

ABSTRACT

The purpose of this study was to investigate the antimicrobial properties of corosolic acids from Lagerstroemia speciosa acetone leaf extracts. The phytochemical analysis was performed to identify the primary and secondary metabolites present in the acetone leaf extracts. The antimicrobial activity of the extracts was evaluated using the agarwell diffusion method in two different wound microorganisms: Grampositive bacteria (Staphylococcus aureus ATCC-25923), Gramnegative bacteria (Escherichia coli ATCC-25922), and Gentamicin (GEN). The results were recorded as the average diameter of the zone of inhibition surrounding the wells containing the test solution. The results showed that the acetone leaf extracts of L. speciosa had significant antimicrobial activity against S. aureus, and corosolic acid was found to be a potent antimicrobial agent. This potential of L. speciosa as a source of biologically active compounds with antimicrobial properties supports further investigation into the use of this plant in the treatment of infections.

Keywords: Antimicrobial, Bacterial strains, Corosolic acid, Lagerstroemia speciosa, Gentamicin,