Abstract

ROLE OF C-PEPTIDE AND C-PEPTIDE GLUCOSE RATIO IN ASSESSING DECREASED BETA CELL FUNCTION IN CHRONIC PANCREATIC DISORDERS

*Sujatha Rani Akuri, Dr. Dawood Suleman

ABSTRACT

C-peptide to Glucose ratio is considered as a better marker for beta cell function in newly detected diabetes patients. Present study, we are studying Serum C-peptide to Glucose ratio levels of 30 chronic pancreatic disorder patients and 20 healthy volunteers to rule out the prediabetes in chronic pancreatic disorder patients. From this study by analyzing the result we found that the mean of fasting serum C-peptide to Glucose ratio levels in cases as 1.267 with a standard deviation of 0.506 is lower when compared with controls with mean value observed in the control group is 2.105 with a standard deviation of 0.732. The P value of fasting serum levels of C-peptide to Glucose ratio in cases and controls is 0.0001. The mean of 2nd hour serum C-peptide to Glucose ratio levels in cases as 4.214 with a standard deviation of 1.647, the mean value observed in the control group is 5.136 with a standard deviation of 0.968 is higher in controls. The P value of 2nd hour serum levels of C-peptide to Glucose ratio in cases and controls is 0.0001, hence there is a significant difference showing low levels in cases. Serum C-peptide to Glucose ratio levels are higher in controls compared to cases. This indicates that there is significant beta cell dysfunction in cases compared to controls. This leads to the diabetic condition in chronic pancreatic disorder patients.

Keywords: C-peptide, beta cell, chronic pancreatic disorder.