Abstract

EFFECT OF ANTIHYPERLIPIDEMIC ACTIVITY OF A POLYHERBAL FORMULATION IN EXPERIMENTAL ANIMALS

Pradnya N. Jagtap, Ashwini M. Kunjir* and Sayali S. Chavan

ABSTRACT

We looked at the antihyperlipidemic properties of a herbal remedy made from a blend of five Indian medicinal plants. The goal of the current study was to use TritonX-100 induced hyperlipidemia to evaluate the polyherbal formulation (Gymnema sylvestre, Aegle marmelos, Commiphora mukul and olea europaea) potential for lowering blood lipids, cholesterol, and triglycerides. The animals were divided into four groups normal control, hyperlipidemic control, hyperlipidemic plus Atorvastatin and hyperlipidemic plus polyherbal formulation. Triton X 100 was administered as a intraperitoneally to cause hyperlipidemia. Plasma levels of cholesterol, triglycerides, non- HDL-C, and phospholipids were dramatically reduced after oral route of polyherbal formulation, while HDL-C levels were significantly raised. Polyherbal formulation exhibited quite competitive potential when compared with the reference drug Atorvastatin affording a possible alternative therapeutic agent in the treatment of hyperlipidemia.

Keywords: Hyperlipidemia, Polyherbal formulation, triton X100.