Abstract

ENHANCEMENT OF SOLUBILITY AND BIOAVAILABILITY OF BCS CLASS II DRUG DORAVIRINE BY SOLID DISPERSION TECHNIQUE

Sushant Pawar*, Dr. Sandip Kshirsagar and Dr. Rupali Dhamdhere

ABSTRACT

The in-vitro release characteristics of the class II active pharmaceutical ingredients according to Biopharmaceutical classification system are very slightly water soluble. Doravirine drug are falls in class II as per BCS classification and possesses limited water solubility, resulting in poor bioavailability. This research was focuses on utilizing solid dispersion techniques to rises the drug solubility, dissolution rate and bioavailability of less aqueous dissolvable, BCS class II drug Doravirine. The dissolution rate from solid dispersion was affected by the carrier concentration. HPMC and PEG-4000 were used as carriers in the preparation of Doravirine solid dispersion and PEG 4000 gives better solubility and drug release than HPMC. And the solid dispersion of Doravirine prepared by methods fusion method and solvent evaporation method. All the prepared Solid Dispersion formulations of both polymers were showed multifold improvement in solubility and rapid drug release in 60 min time, when tested for in vitro dissolution. According to results, it was concluded that Solid dispersion technique was discovered to be effective in increasing the solubility, dissolution, and ultimately bioavailability of less aqueous soluble drug like Doravirine.

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