Abstract

FORMULATION AND EVALUATION OF ORAL DISINTEGRATING TABLETS OF VILDAGLIPTIN

*B. Hari Chithira, A. Sathyaraj, Dr. L. Karpagavalli, Dr. C. Roosewelt

ABSTRACT

Formulation and evaluation of vildagliptin ODT is important in ensuring patient safety and efficacy of the medication. Vildagliptin is a medication used to treat type 2 diabetes, and ODT stands for orally disintegrating tablet. The main advantage of this formulation is that it allows patients who have difficulty swallowing tablets to take the medication without water, making it more convenient. The formulation and evaluation of vildagliptin ODT includes various aspects such as drug release, stabilityy. The formulation of vildagliptin ODT involves the use of different excipients, which enhance the drug's characteristics and ensure optimal drug delivery. The excipients used in vildagliptin ODT may include disintegrants, binders, and lubricants, among others. Disintegrants help break down the tablet when in contact with saliva, while binders ensure the tablet remains intact before ingestion. Lubricants ensure easy tablet handling during the formulation process. The evaluation of vildagliptin ODT involves various tests, such as dissolution testing, stability testing. Dissolution testing assesses the rate and extent of drug release from the tablet, which is important for drug efficacy. Stability testing ensures that the medication maintains its potency and quality over time, even under varying storage conditions. Proper formulation and evaluation ensure that vildagliptin ODT is effective, safe, and stable for consumption. In conclusion, formulation and evaluation of vildagliptin ODT is essential for optimal drug delivery and patient safety. The use of different excipients during formulation enhances drug characteristics, while various tests during evaluation ensure drug efficacy and safety. Patients who have difficulty swallowing tablets can benefit greatly from the convenience of this formulation. Therefore, it is crucial for pharmaceutical companies to undertake proper formulation and evaluation of vildagliptin ODT to ensure optimal Efficacy and Safety for patients.

Keywords: Vildagliptin, Crospovidone, Croscarmellose sodium, Sodium starch glycolate.