Abstract

FORMULATION AND EVALUATION OF NABUMETONE NIOSOMES

Ganesh N. S., Akash Narula*, E. Gopinath and Vineeth chandy

ABSTRACT

The study was undertaken with an aim to formulate and evaluate Niosomal capsule of Nabumetone where the drug is released in a sustained manner for a period of 6 hours. Nabumetone is Class-2 drug having low solubility and bioavailability. Due to high first Pass metabolism, the drug is rapidly excreted from the body indicating the need of sustained Released delivery. To overcome these -limitation, Nabumetone was incorporated in Niosomes. Niosomal drug delivery system was preferred due to improved stability and it carries Significant quantity of drug, thus enhancing the systemic absorption of drug. Two Different non-ionic surfactants namely span 20 and span 60 were used in different ratio for the Preparation of Niosomes. The Niosomes were prepared using ether direct injection method and they were evaluated for morphology, percentage practical yield, percentage entrapment efficiency and in vitro release study. Formulation F5 with drug and non-ionic surfactant span-20 in the ratio of 1:4 was found to be optimized formulation based on evaluation - Parameter. The optimized formulation was further evaluated by SEM. The optimized formulation (F5) was formulated as Niosomal capsule. Formulation F5 With Niosomal formulation shows in vitro drug release of 80.5% at the end of 6 hours.

Keywords: Nabumetone, Niosomes, In vitro drug release.