Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF SOLUBILITY ENHANCEMENT OF ANTIDIABETIC DRUG

Ashwamegh Ahire*, Ragini Bundela, Sneha Singh, Ramakant Sharma, Dr. Karunakar Shukla

ABSTRACT

The poor dissolution of respectively water insoluble drug as for long had been a problem in a formulation of oral dosage form. This limit such as absorption and Bioavailability. Several approaches have been followed in improving solubility of the drug, one of them is solid dispersion to increase the solubility and bioavailability Glimepiride can be formulated in the form of complexes with carrier such as PEG 6000 and HPMC. Solubility of a drug is an important property that mainly influences the extent of oral bioavailability. Enhancement of oral bioavailability of poorly water soluble drugs is the most challenging aspects of drug development. It is very important to find appropriate formulation approaches to improve the aqueous solubility and bioavailability of poorly aqueous soluble drugs. In present work solubility enhancement property of polymer and drug was investigated. Mixtures of drug and gums were prepared by various methods and influence of method of preparation of mixture on solubility was investigated. From all above studied methods, solvent evaporation and fusion methods was optimized and characterized by Determination of solubility, Determination Percentage yields, In-Vitro dissolution studies, Drug content and stability studies to support the results obtained from solubility and dissolution efficiency studies. Finally in vitro studies of prepared formulations further supported the concept of enhancing solubility by these polymers. The compatibility of drug: polymers of solid dispersion was also checked by using X-ray diffraction & also found that there was no change was observed. If studied and applied carefully these polymers can effectively be used in platform technology for enhancing solubility of any drug comes under BCS class II.

Keywords: Antidiabetic, enhancement, Glimepiride, Solubility, X-Ray.