Abstract

DESIGN, DEVELOPMENT AND IN-VITRO AND EX-VIVO STUDY OF TELMISARTAN LOADED MICROSPHERE

Bishan Sarkar*, Snehansu Biswas, Indranil Chatterjee, Rajkumar Ghosh and Ahelee Dutta

ABSTRACT

Introduction:- Microsphere drug delivery system is a one of the unique and novel drug delivery approaches, as it can improve the effectiveness of a drug by maintaining the drug concentration between the MEC and MTC levels inhibiting the dilution of drug in the dilution of drug in the body fluids and allowing targeting and localization of drug at a specific site. Purpose:- The aims & objectives of this research work is to design and develop oral sustained release microspheres of Telmisartan by ionic gelation method. This method is selected for preparing the microsphere due to its low cost and non utility of organic solvents. Results:- The % yield of all the Telmisartan loaded pectinate microsphere formulations (TM 1 to TM 4) was found within the range from 64.9 ± 2.78% to 68.37 ±1.83%. The % entrapment efficiency and particle size of the prepared Telmisartan loaded microsphere formulations (TM1 to TM4) was found within the range from 62.38± 3.51% to 80.62% ± 2.37% and 0.68 ± 0.14 mm to 0.76 ± 0.12 mm respectively. Formulations TM1 to TM4 showed 70.28 % to 86.04 % mucoadhesion up to 6 hours in simulated intestinal fluid (phosphate buffer, pH 6.8). Formulation TM3 was chosen as an optimized Telmisartan loaded microsphere formulation (more than 90% drug was release within 7 hours). FE-SEM of optimized microsphere formulation (TM3) revealed that the microspheres were discrete and almost spherical in shape. FTIR study revealed that there was no interaction between the drug and polymer in the prepared microsphere formulations.

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