Abstract

TRANSDERMAL SUSTAINED AND SAFE RELEASE DRUG DELIVERY SYSTEM

Ritakshi*, Arti Kori and Dr. S. M. Patil

ABSTRACT

Transdermal drug delivery system is the most preferable route of drug administration. This route has high acceptability because of the safe and effective delivery of drugs. The human skin is a readily accessible surface for drug delivery. The skin of an average adult body covers a surface of approximately 2 m2 and receives about one-third of the blood circulating through the body. Over the past decades, developing controlled drug delivery has become increasingly important in the pharmaceutical industry. The human skin surface is known to contain, on average, 10- 70 hairs follicle and 200-250sweat ducts on every square centimeter of the skin area. It is one of the most readily accessible organs of the human body. There is considerable interest in the skin as a site of drug application for local and systemic effects. However, the skin, in particular the stratum corneum, poses a formidable barrier to drug penetration thereby limiting topical and transdermal bioavailability. Skin penetration enhancement techniques have been developed to improve bioavailability and enhance the range of drugs for which topical and transdermal delivery is a viable option. During the past decades, the number of drugs formulated in the patches has hardly enhanced, and there has been little change in the composition of the patch system. Modifications have been mostly limited to the refinement of the material used. The present review article explores the overall study on transdermal drug delivery systems which lead to novel drug delivery systems.

Keywords: Transdermal drug delivery, permeation enhancer, topical, epidermis.