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FORMULATION DEVELOPMENT AND CHARACTERIZATION OF TRANSETHOSOMAL DELIVERY OF BABCHI OIL FOR ANTI-PSORIATIC AND ANTI-FUNGAL ACTIVITY
Dr. A. Abdul Hasan Sathali* and V. Celin Janet
ABSTRACT Psoriasis and fungal infections present significant challenges in dermatological treatment, necessitating the development of effective therapeutic approaches. This study focuses on the formulation development and characterization of transethosomal delivery of Babchi oil, aiming to improve its anti-psoriatic and anti-fungal activity. The transethosomal formulations were prepared by using a cold method. Two sets of 32 factorial design were employed to optimized the formulations, considering factors such as edge activator and ethanol concentration. The optimized formulations were incorporated into Carbopol 940 gel base. The prepared Babchi oil- loaded transethosomes were further characterized for vesicle size, polydispersity index, entrapment efficiency, zeta potential, drug content, in-vitro drug diffusion study through egg membrane. The optimized Babchi oil-loaded transethosomal gel were further studied for in-vitro antioxidant activity by DPPH assay, in-vitro anti-inflammatory assay by protein denaturation assay and in-vitro antifungal assay. The in-vitro drug release study was compared between optimized formulation containing Tween 80 (BOTE-F5) and Span 80 (BOTE-F5b). The results showed that the prepared transethosomes have vesicle size in the range between 109.6nm to 259.9nm for transethosomes containing Tween 80 as an edge activator, 121.9nm to 273nm for transethosomes containing Span 80. The formulations show high entrapment efficiency, zeta potential values shows that the formulation has good stability. The optimized BOTE gels follow zero order release kinetics. The optimized formulations exhibited moderate antioxidant and anti-inflammatory activity. These findings underscore the therapeutic potential of BOTE gel for the treatment of psoriasis, fungal and associated anti-inflammatory and oxidative stress conditions. Keywords: Babchi oil, Cold method, transethosomes, factorial design, in-vitro characterization. [Download Article] [Download Certifiate] |