Abstract

REPURPOSING PENFLURIDOL AS ANTI-CANCER AGENT

Chen Jiajun*, Barani Karikalan and Srikumar Chakravarthi

ABSTRACT

Drug repurposing, also known as drug repositioning, is the process of identifying new therapeutic uses for existing drugs that were originally developed for a different purpose. This strategy can potentially expedite the development of new treatments by leveraging the known safety profiles and mechanisms of existing drugs. Penfluridol is an antipsychotic medication that has been investigated for potential repurposing as an anticancer agent in recent years. Researchers have explored its effects on various cancer types, including breast cancer, glioblastoma, and colorectal cancer. Some studies and preclinical research have suggested that penfluridol may exhibit anticancer. Properties through mechanisms such as: 1. Inhibition of Cancer Cell Proliferation: Penfluridol has been shown to inhibit the growth and proliferation of cancer cells in laboratory settings. It may interfere with signaling pathways that contribute to uncontrolled cell division. 2. Induction of Apoptosis: Apoptosis is a process of programmed cell death that is often dysregulated in cancer. Penfluridol has been investigated for its potential to induce apoptosis in cancer cells, leading to their death. 3. Anti-Angiogenic Effects: Penfluridol may have anti-angiogenic properties, meaning it could inhibit the formation of new blood vessels that supply nutrients to tumors. This could potentially limit the tumor's ability to grow and spread. 4. Modulation of Cellular Signaling: Penfluridol might affect various cellular signaling pathways involved in cancer development and progression. This modulation could interfere with processes necessary for tumor growth. 5. Enhanced Chemotherapy Sensitivity: Some studies have suggested that penfluridol could sensitize cancer cells to the effects of chemotherapy, potentially making standard chemotherapy regimens more effective. It's important to note that while there is promising preclinical data suggesting the anticancer potential of penfluridol, clinical trials are needed to determine its effectiveness and safety in human cancer treatment. The transition from preclinical studies to clinical trials is a critical step in evaluating whether a repurposed drug like penfluridol can provide meaningful benefits to cancer patients.

Keywords: .