Abstract

A REVIEW ON SYNTHETIC APPROCHES AND BIOLOGICAL ACTIVITIES OF AZETIDIN-2-ONE LINKED HETEROCYCLIC DERIVATIVES

Anitha Sadula*, Vaishnavi Arrolla, Ramakrishna Kodi and Divya Vani Gampala

ABSTRACT

Heterocyclic chemistry is regarded as a multifaceted area that investigates the synthesis, characterisation and various applications. The overview of recent approaches for the synthesis of azetidine-2-one derivatives was made as a result of prestigious position that chemistry of β-lactam has acquired in organic and medicinal chemistry and it is a lead molecule for the development of possible bioactive substances, additionally diverse synthetic information. Many of the heterocyclic structures fused to the four-membered ring, the cyclic azetidin-2-one has served as a template. The antibacterial characteristics of penicillin and cephalosporins have drawn particular attention to azetidin-2-ones. These are a special class of compounds that have been linked to a variety of biological activities such as antibacterial, anti-tubercular, anticancer, anti-inflammatory, CNS activity, antihyperglycemic, antitumor, antimicrobial and enzyme inhibitors etc. This present article briefly discusses about the conventional synthesis along with certain green synthetic methods and biological activities of azetidine-2-ones to facilitate and improve potential future research on new medications that can be introduced to the market quickly, effectively and sustainably.

Keywords: Azetidin-2-one, ?-lactam, Synthetic methods, Biological activities, Antimicrobial.