Abstract

COMPARISON OF EFFICACY AND SAFETY PROFILE BETWEEN TAMSULOSIN CONTINUS® CONTROLLED RELEASE PREPARATION AND TAMSULOSIN SUSTAINED RELEASE PREPARATION IN PATIENTS OF BENIGN PROSTATIC HYPERPLASIA SUFFERING FROM LOWER URINARY TRACT SYMPTOMS

*Amit Jain¹, Jatinder Singh², Surinder Gupta³, Vikas Gupta⁴

¹Department of Pharmacology, Government Medical College, Amritsar
²Department of Pharmacology, GGS Medical College, Faridkot
³Department of Surgery, Government Medical College, Amritsar
⁴University Centre of Excellence in Research, BFUHS, Faridkot. India.

ABSTRACT

Purpose: To compare efficacy and safety profile between tamsulosin continus® controlled release preparation and tamsulosin sustained release preparation in patients of benign prostatic hyperplasia (BPH) suffering from lower urinary tract symptoms (LUTS). Materials and Methods: This open labeled, prospective, randomized, parallel group, intention to treat study was conducted at Government Medical College, Amritsar. Sixty patients selected from the OPD of Department of Surgery, Guru Nanak Dev Hospital, Amritsar attached to Government Medical College, Amritsar were randomly divided into two groups. They were subjected to Tab tamsulosin continus controlled release preparation 0.4 mg once daily in group I and Tab tamsulosin sustained release preparation 0.4 mg once daily in group II. The effect of the preparations of tamsulosin on IPSS score, QOL score, prostate size and residual urine volume was evaluated. Incidence of adverse events was also noted. Results: At the end of the study, there was a significant decrease from 18.333 ± 4.205 to 10.700 ± 3.993 at week 12 in IPSS as compared to the baseline (p

Keywords: Tamsulosin continus® controlled release, Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms, IPSS score, residual urine volume, prostate size.