Abstract

A DETAILED STUDY REVIEW ON SUPERDISINTEGRANTS

Nandanee Patel, Mona Gupta*, Dr. H. D. Karen and Shruti P. Patel

ABSTRACT

In dosage forms, solid dosage forms gain maximum popularities, about 85%, because of many advantages over others. Disintegration plays a major role in improving drug activity and hence increases patient compatibility. The therapeutic activity of the formulations is obtained by disintegration followed by dissolution. The inclusion of right disintegrants is a prerequisite to get optimal bioavailability in tablets and capsules. Disintegrants are substances or a mixture of substances added to the drug formulation that facilitates the breakup or disintegration of tablet or capsule content into smaller particles that dissolve more rapidly than in the absence of disintegrants. Superdisintegrants are generally used at a low level in the solid dosage form, typically 1-10 % by weight relative to the total weight of the dosage unit. The present study comprises the various kinds of super disintegrants which are being used in the formulation to provide safer, effective drug delivery with patient's compliance. In this review article, more emphasis is given on the application and usage of various natural super disintegrants comparing with other disintegrants about available scientific studies.

Keywords: Solid dosage forms, Disintegrants, Natural superdisintegrants.