Abstract

BIGELS- A COMPREHENSIVE REVIEW

Sulendra Singh, Anna Balaji and Shaheen Sultana*

ABSTRACT

Bigels are typically created by combining two types of gels: an organogel and a hydrogel. Typically, a hydrophilic biopolymer forms the aqueous phase, and an organogelator creates a gelled vegetable oil in the organic phase. For the production of bigel, it is necessary to take into account the ratio of the corresponding gelling agent in each phase, the temperature and speed of the mixing, and the organogel/hydrogel ratio. Bigels have already been developed for transdermal, buccal, and vaginal routes and are very excellent drug delivery methods. The most frequently mentioned characterization methods are mechanical evaluations and microscopy. Their composition and distinctive structure, as we will describe here, give intriguing drug delivery properties, such as mucoadhesion, the capacity to regulate drug release, and the potential to combine hydrophilic and lipophilic medications in a single system.

Keywords: Bigels, Hydrogels, Organogel, Organogelator, evaluations, mucoadhesion.