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FORMULATION AND IN-VITRO EVALUATION OF IMMEDIATE RELEASE TABLETS CONTAINING ANTIPLATELET DRUG: CLOPIDOGREL
Srikant Pimple*, Pravin Maurya, Akash Joshi, Amit Jain, Dr. Mukund Gurjar,Mahesh Shah
ABSTRACT
The present investigation was undertaken with an aim to develop pharmaceutically equivalent, stable, cost effective, and quality improved formulation of Clopidogrel bisulfate immediate release tablets. The current study involves formulation and evaluation of Clopidogrel bisulfate immediate release tablets, comparison of dissolution rate of optimized formula with innovator and estimation of similarity factors. Preformulation study such as solubility analysis, intrinsic dissolution, drug-excipients compatibility and hygroscopicity was conducted. Initial batches were formulated by direct compression technique, using roller compaction approach but it resulted in surface irregularities of tablets like sticking and capping. Next trials were Keywords: Clopidogrel Bisulfate, Dissolution, Disintegration time, Colloidal mill, Stability Studies, Release kinetics. [Download Article] [Download Certifiate] |