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FORMULATION AND EVALUATION OF LISINOPRIL ORALLY DISINTEGRATING TABLETS
Mahmoud Mahyoob Alburyhi*, Abdalwali Ahmed Saif, Maged Alwan Noman, Yahya Abduh Salim Mohamed and Mohammed Abbas Hamidaddin
ABSTRACT
Orally disintegrating drug-delivery system server major benefit over the conventional dosage forms because the drug disintegrates rapidly and dissolve in saliva without the use of water. Lisinopril dihydrate is long-acting angiotensin-converting enzyme (ACE) inhibitor, used in treat hypertension, heart failure and myocardial infarction. the drug to be absorbed slowly and incompletely from GI tract, bioavailability 25% and onset of action is 1 hr. in order to increase the bioavailability and improve onset of action. Lisinopril was formulated as orally disintegrating tablets. Six formulations were prepared using (talc, saccharin sodium, PVP K30, sodium starch glycolate, crospovidone, croscarmellose sodium, aspartame, aerosol, sodium lauryl sulfate, avicel pH101, mannitol, Mg stearate and Roseberry flavor). Among all formulations F1 formulation containing (sodium starch glycolate as Keywords: Orally disintegrating tablets, Lisinopril dihydrate, Superdisintegrants, Antihypertensive. [Download Article] [Download Certifiate] |