Abstract

A MINI RESEARCH ON MARKERS USED FOR BONE TURNOVER: BONE FORMATION, BONE RESORPTION AND THEIR EFFECTIVENESS IN VIEWING THE RESULTS

Kong Huanyu*, Qi Zhanpeng and Nadiah Syafiqah Nor Azman

ABSTRACT

Osteoporosisis a major health issue. By 2050, a greater than 2-fold increasein patients number withhip fractures will occur in Asia representing 50% of all hip fractures worldwide. For the Asia-Pacific (AP) region, more efforts on controlling osteoporosis and the subsequent fractures are crucial. Bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA) is commonly used to diagnose osteoporosis and monitor osteoporosis treatment. However, the inconvenience, cost, limited availability of DXA and the delay in detection of BMD changes after treatment initiation support an important role for bone turnover markers (BTMs), as short-term tools to monitor therapy. With regards to low adherence rates of medical treatment of osteoporosis, use serum C-terminal telopeptide oftype 1 collagen(CTX) and serumpro collagen type 1 N propeptide (P1NP), as short-term monitoring tools to help clinicians assess the responses to osteoporosis therapies and appropriately adjust treatment regimens earlier than BMD. Either the absolute values or the degree of change from baseline in BTMs can be used to monitor the potential efficacy of osteoporosis therapies.

Keywords: Osteoporosis; anti-resorptives, Markers of bone formation, Markers of bone resorption, Drugs used in osteoporosis.