Abstract

ACTIVATED CHARCOAL AND DERIVATE MATERIALS IN DRUGS AND BIOPHARMACEUTICAL PURIFICATION:IMPURITY ASPECTS

*Luisetto M., Edbey K., Tarro G., Nili B. Ahmadabadi, Farhan Ahmad Khan, Dr. Zaineb Omar Ettarhouni, Riccardo Benzi Cipelli, Ahmed Yesvi Rafa, Mashori Gulam Rasool, Fiazza C., Cabianca L., Latyshev O. Y.

ABSTRACT

In literature are reported various use of activated charcoal and derivates in biopharmaceutical purifications. Aim of this work is to verify impurity proficle when using this technology. Various commercial product are reported here but it is not the scope of this work put in relation with any toxicological reaction: only to describe the tecnique used in this field. Because various drugs and bioproduct need purification steps it if of interest to see some material science peculiarity. Are involved not only innovative vaccine but also protein and mabs and other. In this work various material science concepts are usefull to better understand some impurity situations. Various commercial products are reported only for scientic reason : it is not the main focus to verify the relationship or not with impurity profile of the product of purification using this materials.

Keywords: Activated charcoal, graphene, composite materials, material science, chromatography, API, purification, biopharmaceuticals, impurity, particle size, toxicology, regulatory.