Abstract

FORMULATION AND EVALUATION OF NEEM OIL CREAM FOR TREATING FUNGAL INFECTION

Neelam Kushwaha*, Jai Narayan Mishra, Amit Kumar Shukla and D.K. Vishwakarma

ABSTRACT

The purpose of this study was to ascertain the antimicrobial effects of neem oil cream formulations on the fungal strain, Candida albicans, which cause skin diseases and are becoming more and more resistant to many commonly used antibiotics as a result of colonisation of the skin. The preparation of five distinct cream formulations was evaluated for homogeneity, phytochemical tests, drug content, in-vitro drug release, and antifungal research. Results showed that the pH of the cream was discovered to be in the range of 5.8-6.7, which is good for the skin pH. Neem oil was also shown to include alkaloids, glycosides, saponins, and flavonoids. Every composition was quite close to the pH of the skin. All of the formulations were confirmed to have good pH and viscosity throughout our physicochemical evaluation procedures.

Keywords: Antifungal; Skin Cream; Neem oil; Candida albicans; Antibiotics; Resistance.