Abstract

MICROWAVE ASSISTED SYNTHESIS AND IN VITRO ANTIMALARIAL SCREENING OF NOVEL PYRIMIDINE DERIVATIVES

Dayena J. Christian, Manoj N. Bhoi, Mayuri A. Borad, Dhanji P.Rajani, SmitaD.Rajani, Hitesh D. Patel*

ABSTRACT

This research article mainly emphases on recent endeavors in the field of heterocyclic compounds. Pyrimidines have extensively explored in medicinal chemistry because of their wide range of biological activities. Keeping this in view, we have synthesized some novel pyrimidine derivatives from novel chalcones by the condensation reaction with guanidine hydrochloride/thiourea. All these synthesized compounds were characterized by IR, 1H NMR, Mass spectral dataandelemental analysis. These compounds were also screened for In Vitroanti-malarial activity. Among all evaluated compounds, the molecule 5cand 7c exhibit the most pronounced excellent anti-malarial activity IC50Value (μg/mL) 0.028, 0.078 respectively.

Keywords: Anti-malarial agent, Amino-pyrimidine, Chalcones,Microwave assistant reaction, Plasmoduim falciparum, Pyrimidines.