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DEVELOPMENT AND VALIDATION OF SIMPLE UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF CYCLOBENZAPRINE BOTH IN BULK & IN MARKETED DOSAGE FORMULATION
Chetna Ramchandra Madke*, Hitesh Motilal Jain,Minal T. Harde,Pravin D. Chaudhari
ABSTRACT A rapid, simple & economic UV spectrophotometric method was developed & validated for estimation of cyclobenzaprine hydrochloride in bulk & pharmaceutical dosage formulation. At the predetermined absorbance maxima of 290nm, the calibration curve linear in the range of 4-24 μg/ml & has correlation coefficient R2=0.999 & good mean recovery (99.04-100.89 %). The method is developed using methanol &water as a solvent & results were validated as per ICH guidelines for Accuracy, precision, linearity, LOD, LOQ & found to be satisfactory. Keywords: Cyclobenzaprine hydrochloride, UV spectrophotometry, Validation [Download Article] [Download Certifiate] |